Morley RL, Sharma A, Horsch AD, Hinchliffe RJ, Peripheral artery disease, BMJ 360 (2018), j5842, 10.1136/bmj.j5842. American, Heart disease and stroke statistics-2021 update: A report from the American Heart Association, in: Circulation vol. Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Cheng S, Delling FN, Elkind MSV, Evenson KR, Ferguson JF, Gupta DK, Khan SS, Kissela BM, Knutson KL, Lee CD, Lewis TT, Liu J, Loop MS, Lutsey PL, Ma J, Mackey J, Martin SS, Matchar DB, Mussolino ME, Navaneethan SD, Perak AM, Roth GA, Samad Z, Satou GM, Schroeder EB, Shah SH, Shay CM, Stokes A, VanWagner LB, Wang NY, Tsao CW, H.A.C.O.E.A.P.S.C.A.S.S.S. GBD, Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet 392 (2018) 1736–1788, 10.1016/S0140-6736(18)32203-7.ĭ.A.I.C. This review provides a comprehensive overview of the different polymers, techniques, and functionalization approaches that have been used to develop an electrospun tissue engineered vascular graft.Įlectrospinning Scaffold Vascular tissue engineering.Ĭopyright © 2021 Elsevier B.V. Electrospinning presents a promising approach to the development of a suitable tissue engineered vascular graft. To achieve long term patency, a successful tissue engineered vascular graft would need to closely match the mechanical properties of native tissue, be non-thrombotic and non-immunogenic, and elicit the proper healing response and undergo remodeling to incorporate into the native vasculature. Although medium to large diameter synthetic vessels are in use, no suitable small diameter vascular graft has been developed due to the unique dynamic environment that exists in small vessels. Due to the prevalence of cardiovascular diseases, there is a large need for small diameter vascular grafts that cannot be fulfilled using autologous vessels.
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